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Online Men’s Telehealth for Hormone, Metabolic & Preventive Care

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Licensed U.S.Clinicians & Licensed U.S. Pharmacies

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100% Telehealth, Pharmacy-Shipped to Your Door

Oral Testosterone (Kyzatrex®)

FDA-Approved Oral Testosterone Therapy

Prescription-only softgel formulated for men who may require testosterone replacement under licensed clinician supervision.

Skip injections with an FDA-approved oral testosterone option designed for clinically appropriate testosterone replacement therapy, determined through a comprehensive telehealth evaluation.

Clinical Context

Testosterone replacement therapy is prescribed only when clinically appropriate, based on medical history, reported symptoms, and laboratory evaluation.
Under clinician guidance, testosterone therapy has been studied for its role in supporting:

  • Energy and daytime vitality

  • Mood stability and mental focus

  • Lean mass maintenance

  • Bone health

  • Sexual health function in men with diagnosed testosterone deficiency

Common Symptoms Reviewed During Evaluation

Licensed clinicians may evaluate symptoms such as:

  • Persistent fatigue or low energy

  • Reduced libido

  • Changes in strength or body composition

  • Slower recovery

  • Mood changes or irritability

  • Difficulty with focus or mental clarity

How Kyzatrex® Works

Powered by Kyzatrex®, this modern oral testosterone formulation uses a proprietary Self-Emulsifying Drug Delivery System (SEDDS).
Unlike earlier oral testosterone formulations, this lipid-based delivery system is designed to be absorbed via the intestinal lymphatic pathway, a route involved in normal fat and nutrient absorption.

This formulation approach has been studied in clinical settings and differs from older oral testosterone products in how testosterone enters systemic circulation.

Program Features

  • Physician-guided telehealth clinical evaluation

  • Personalized care plan determined by a licensed clinician

  • FDA-approved prescription medication, when clinically appropriate

  • Ongoing follow-up care and routine monitoring

  • Secure clinician messaging via your patient portal

Lab Monitoring (Included with Eligible Plans*)

  • Initial blood panel and clinician review

  • 3-month follow-up blood panel and clinician review*

  • 6-month routine monitoring blood panel and clinician review (every 6 months)*

Prescription Care

Monthly Program

$199 / month

First + Final month to start • Clinician-authorized • Dispensed by licensed U.S. pharmacies • Shipping included

 

Get Started Today
Care Experience Ideal Use Application Ingredients

Format: Oral softgel capsule

Status: Prescription-only (CIII)

Access: Telehealth consultation required

Mechanism: Lymphatic absorption via lipid-based delivery system

Treatment Details

Lab monitoring included with eligible plans*

Telehealth clinical evaluation with a licensed clinician

Personalized care plan determined by the clinician based on history, symptoms, and labs

Prescription medication and required supplies included when prescribed

Follow-up care and ongoing monitoring per clinician-directed schedule

Secure clinician messaging through your patient portal

Status: Prescription (RX) Only — telehealth evaluation required

Important Disclosures Testosterone replacement therapy is not appropriate for all individuals.
Prescription issuance is not guaranteed and is determined solely by a licensed clinician.
This program does not promise specific outcomes. Individual responses vary.

*Monthly automatic billing is required for plans that include laboratory testing (if applicable). Patients may be responsible for additional laboratory costs if repeat testing is clinically indicated or if testing is performed outside the included schedule.

Testosterone replacement therapy may be considered for adult men with clinically confirmed testosterone deficiency (hypogonadism), as determined by a licensed clinician following a comprehensive medical evaluation and laboratory review. TRT is prescription-only, is not appropriate for everyone, and individual responses vary.

During evaluation, some men with low testosterone may report symptoms such as:

  • Persistent low energy or fatigue

  • Reduced libido

  • Difficulty maintaining muscle mass

  • Changes in motivation or overall sense of well-being

Administration (Clinician-Directed)

Route: Oral softgel capsule, taken by mouth as prescribed by the licensed clinician.

Frequency: Determined by the prescribing clinician based on individual medical evaluation, laboratory review, and ongoing clinical considerations.

Instructions: Patients receive guidance on proper use through the care team and patient portal. Do not start, stop, or adjust dosage or schedule without clinician approval.

Active Ingredient: Testosterone Undecanoate (CIII). A fatty-acid ester of testosterone.

Delivery Matrix: Phytosterol esters and DL-alpha-tocopherol (Vitamin E) formulated to bind with dietary fats for lymphatic uptake.

Inactive Ingredients: Gelatin, glycerin, purified water.

Benefits Of Testosterone Replacement Therapy

Mood & Emotional Well-Being Support

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Testosterone plays a role in emotional regulation. In men with clinically confirmed low testosterone, therapy may help support mood and overall sense of well-being when provided under clinician supervision.

Energy & Mental Well-Being Support

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Testosterone plays a role in overall well-being. In men with clinically confirmed low testosterone, therapy may help support energy levels and mood under clinician supervision.

Sexual Function Considerations

Simplification

For men with clinically confirmed low testosterone, therapy may help support libido and aspects of sexual health when medically appropriate and clinician supervised.

Mental Well-Being Considerations

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Testosterone is involved in normal neurologic function. In men with deficiency, therapy may help support overall mental well-being and quality of life as part of a clinician-directed treatment plan.

Bone Density Considerations

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Testosterone contributes to bone health. In men with deficiency, therapy may help support bone mineral density when clinically appropriate.

Lean Mass & Body Composition Support

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In appropriately selected patients, testosterone therapy may help support the maintenance of lean muscle mass when combined with healthy nutrition and physical activity.

Get Started Today

Get Started In 3 Simple Steps

STEP 1

Complete Telehealth Intake

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A licensed U.S. clinician then reviews your medical history and lab work if required to determine eligibility for care.

STEP 2

U.S Pharmacy Delivery

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If prescribed, treatment is dispensed by a licensed U.S. pharmacy & Shipped discreetly to your door.

STEP 3

Ongoing Clinician Guided Care

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Clinicians provide follow-up to review labs and adjust treatment when medically appropriate, supporting individualized care.

Get Started Today

What Patients Say

The onboarding was straightforward and everything was explained clearly. The clinician took time to review my history and labs and answered my questions without rushing. I appreciated the follow-up plan and knowing what to expect next.

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James A.

Weight Managment

Communication was prompt and professional. Scheduling was easy, and the care team helped me understand the steps from assessment to clinician review. Overall, the experience felt organized and respectful of my time!

Robert H

Robert H.

Hormone Care

After my evaluation, the clinician discussed options and went over monitoring. When a prescription was appropriate, my medication was shipped from a licensed U.S. pharmacy and arrived as expected. The check-ins and reminders helped me stay on track.

Bill D

Bill D.

Longevity

Why Patients Choose TRTBOSS

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Personalized Plans

Care options aligned to your goals, based on individualized clinical review

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Clinician Review + Labs

Start with an online intake. Clinicians may order and review lab work when clinically appropriate.

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Ongoing Monitoring

Follow-ups and adjustments are guided by a licensed clinician based on symptoms, history, and lab results.

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Get Started Today
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Evidence-Informed Options

Clinician-guided discussion of options for men’s health concerns, based on your evaluation and medical history.

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Care Coordination & Support

Reminders, education, and help navigating next steps—so you know what happens before and after your visit.

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Private Care

Confidential support with secure messaging and account access.

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How Clinically Supervised Testosterone Optimization Restores Male Physiology

Testosterone Replacement Therapy (TRT) is a medically prescribed treatment designed to restore testosterone levels to an optimal physiological range. By directly addressing the hormonal root cause of fatigue, low libido, muscle loss, and cognitive decline, TRT helps normalize energy production, muscle protein synthesis, mood regulation, and metabolic function.

Unlike supplements or lifestyle-only approaches that attempt to stimulate hormone production indirectly, clinically supervised TRT delivers precision-dosed testosterone under physician monitoring, ensuring consistent, effective restoration without hormonal instability. This targeted medical approach supports sustainable strength, mental clarity, sexual health, and long-term vitality—without the crashes or guesswork of non-clinical solutions.

Get Started Today

Switch Confidently From Your Current Provider to TRTBOSS

Better Value. Transparent Pricing. Complete Support.

Make the switch to TRTBOSS and experience affordable, high-quality treatment that’s 100% online, discreet, and designed for your lifestyle.

Comparison TRTBOSS vs Other Clinics

Feature

  • Initial Lab work + Consult
  • Monthly Treatment Plans
  • LegitScript Verified
  • Membership Fee
  • Medications
  • Ongoing Physician Communication
  • Supplies
  • Medication Quality
  • Convenience
  • Ongoing Support
  • Research Grade Compounds
  • Labs
  • Cost to start

Other Clinics

  • $149 – $799
  • $199 – $299/month
  • Unknown
  • $19 – $49 per month
  • Up to $99 (plus fees)
  • Up to $199 per consult
  • Up to $70 annually
  • Unknown
  • Commute + waiting rooms
  • Extra fees for follow-ups
  • Unknown
  • Extra
  • 3 to 6 months of service

TRTBOSS TRT

  • $160 FSA / HSA Eligible
  • $169/month FSA / HSA Eligible
  • Yes
  • None
  • Included
  • UNLIMITED through your patient portal
  • Included
  • Licensed US pharmacies
  • 100% online, discreet
  • Unlimited
  • Never
  • Included
  • First + Last

The Proof Is in Their Journey

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Trusted. Certified. Confidential.

At TRTBOSS Every step is supported through a clinician-led process with independent, U.S. Licensed clinicians. If prescribed, medications are dispensed and shipped by Licensed U.S LegitScript-certified pharmacies. From expert medical oversight to discreet delivery, We prioritize privacy, secure communications, and clear next steps throughout your experience.

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Customer Reviews

All Reviews

Latest Write a Review

Posted on August 14, 2023

Samantha D.

TRTBOSS has truly changed my life. The process was smooth, the team was supportive, and the results speak for themselves. I feel more energetic, confident, and focused than ever. It’s easily the best decision I’ve made for my health.

Posted on August 14, 2023

Samantha D.

TRTBOSS has truly changed my life. The process was smooth, the team was supportive, and the results speak for themselves. I feel more energetic, confident, and focused than ever. It’s easily the best decision I’ve made for my health.

Posted on August 14, 2023

Samantha D.

TRTBOSS has truly changed my life. The process was smooth, the team was supportive, and the results speak for themselves. I feel more energetic, confident, and focused than ever. It’s easily the best decision I’ve made for my health.

Posted on August 14, 2023

Samantha D.

TRTBOSS has truly changed my life. The process was smooth, the team was supportive, and the results speak for themselves. I feel more energetic, confident, and focused than ever. It’s easily the best decision I’ve made for my health.

Let’s Get Started Load More Reviews

Frequently Asked Questions

Unlike older forms (like Methyltestosterone) which were liver-toxic, Kyzatrex® is absorbed through the lymphatic system rather than the portal vein. This bypasses the liver significantly, maintaining a safety profile comparable to transdermal gels regarding liver enzymes.

Clinical data shows it is highly effective. In pivotal trials, the vast majority of participants achieved effective therapeutic levels. While injections are the historical “gold standard” for absorption, this oral protocol is the leading non-invasive alternative.

It can. Clinical studies showed a small increase in blood pressure in some men. We require all patients on the Oral Protocol to monitor their BP at home. (See Boxed Warning below).

This specific webpage is for Oral Testosterone monotherapy. However, hCG (injectable) can often be prescribed alongside this protocol if maintaining testicular volume and fertility is a priority for you. Ask your provider during your consult.

Medical Citations & Positive Health Publications
Clinical Basis for Therapy:

1. TRT’s Impact on Body Composition- A study demonstrated that a 10-week regimen of Testosterone Replacement Therapy (TRT), when paired with a disciplined diet and exercise plan, led to substantial gains in fat-free mass and muscle size. Utilizing advanced measurement techniques, such as underwater weighing and magnetic resonance imaging, the findings confirmed significant improvements in overall body weight and the muscle size of major muscle groups.
https://pubmed.ncbi.nlm.nih.gov/9024227/

2. TRT Improves Sexual Function and Satisfaction- High-quality evidence demonstrates that Testosterone Replacement Therapy (TRT) is linked to significant improvements in sexual health for men with low testosterone (hypogonadism) when compared to a placebo. These benefits include a substantial enhancement in:
Sexual desire (libido)
Erectile function (EF)
Sexual activity
Sexual satisfaction
https://academic.oup.com/jcem/article/103/5/1745/4939466?login=false

3.TRT and Cognitive Function- Promising research links testosterone supplementation to improved cognitive function in men, including those with normal testosterone (eugonadal) and those with low levels (hypogonadal), regardless of their starting cognitive status. Low natural testosterone levels may be associated with reduced cognitive ability, and supplementing with testosterone may lead to improvements in certain cognitive skills. A study spanning two years on young and middle-aged hypogonadal men demonstrated that Testosterone Replacement Therapy (TRT) enhanced:
Attention
Visual scanning ability
Executive function
Psychomotor speed
https://onlinelibrary.wiley.com/doi/10.1111/and.12633
https://academic.oup.com/ejendo/article-abstract/155/6/773/6695703?redirectedFrom=fulltext

4. TRT and Mood Enhancement- Testosterone replacement therapy in men with low testosterone (hypogonadism) improved their mood by:
Improving positive mood parameters such as energy, well-being, and friendliness.
Decreasing negative mood parameters including anger, nervousness, and irritability.
https://pubmed.ncbi.nlm.nih.gov/8855804/

5. Advanced Oral Testosterone Formulation- Our FDA-approved oral testosterone is engineered for highly efficient and specific lymphatic absorption. This innovative design allows the medication to bypass the liver, thereby avoiding the liver toxicity traditionally associated with older oral testosterone medications. Furthermore, clinical monitoring of liver markers in patients using this formulation has consistently shown no acute adverse effects on liver function.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126116/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558846/

Efficacy: Kyzatrex® Clinical Trials (NCT03198728). Results showed 96% of compliant patients achieved mean plasma testosterone concentration within the normal range (222–800 ng/dL) after 90 days of treatment.

Safety Profile: Swerdloff, R. S., et al. (2020). Oral Testosterone Undecanoate: A Review of the Clinical Data. Journal of Endocrine Society. (Discusses the safety of lymphatic-absorbed testosterone regarding liver enzyme stability).

Absorption Mechanism: Shackleford, D. M., et al. (2003). The role of lymphatic transport in the oral bioavailability of testosterone undecanoate. (Establishes the science behind bypassing first-pass liver metabolism).

IMPORTANT SAFETY INFORMATION
BOXED WARNING: BLOOD PRESSURE INCREASES
Kyzatrex® can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal heart attack, non-fatal stroke, and cardiovascular death.
Your provider will check your BP before starting and periodically during treatment. If your BP rises, treatment may need to be stopped or BP medication added.
Contraindications: Do not use if you have breast cancer, known/suspected prostate cancer, or are allergic to ingredients in Kyzatrex.
Side Effects: Common side effects may include high blood pressure, headache, and increased red blood cell count (polycythemia).
Rx Only: This is a controlled substance. Misuse may lead to serious cardiac or psychological side effects.

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