RX-Only U.S. Licensed Medical Providers U.S. Licensed Pharmacies Legitscript Certified HSA/FSA Eligible Telehealth Convenience Discreet Shipping
Sema + b12
Sema + b12
prodebanleb-img1

Online Men’s Telehealth for Hormone, Metabolic & Preventive Care

prodebanleb-img2

Licensed U.S.Clinicians & Licensed U.S. Pharmacies

prodebanleb-img3

100% Telehealth, Pharmacy-Shipped to Your Door

Clinician-Directed Semaglutide + B12 Weight Management Care

Modern GLP-1 Weight Management, Prescribed by Licensed Clinicians. Any Dose, One Cost.

Clinician-directed GLP-1 care that may support appetite regulation and metabolic health as part of a comprehensive weight-management plan. One monthly price across clinician-determined doses

In clinical studies, GLP-1 is associated with

  • Reduced appetite and decreased caloric intake in appropriate patients

  • Gradual weight reduction with ongoing medical oversight

  • Improvements in certain cardiometabolic markersin some patients, alongside nutrition and activity plans

About supportive nutrients 

Vitamin B12

  • Supports normal energy-producing metabolic pathways

  • Plays a role in red blood cell formation and neurologic function

  • Commonly evaluated in patients undergoing long-term metabolic care

Designed for Adults Seeking

  • Clinician-guided, prescription-based weight-management care

  • Support with appetite regulation alongside nutrition and activity efforts

  • A structured telehealth program rather than over-the-counter supplements

  • Ongoing medical oversight and follow-up

  • Transparent, predictable monthly pricing

The Clinical Difference: Prescription Compounding vs. Non-Clinical Products

Through the TRTBOSS platform, GLP-1 therapies are available only after an evaluation by a licensed clinician and, when prescribed, are dispensed by licensed U.S. pharmacies for patient use under medical supervision.

TRTBOSS DOES NOT source, dispense, or provide “research grade,” research-labeled, or “for research use only” products for patient use. Products carrying these designations are not dispensed pursuant to a valid prescription and are not incorporated into clinician-guided treatment plans.

When a clinician determines treatment is appropriate, compounded Semaglutide + B12 medications are prescribed based on an individual medical evaluation and prepared by licensed pharmacies operating under applicable compounding regulations. Medications are dispensed for patient use within a supervised clinical context, with appropriate documentation, counseling, and continuity of care.

Program Features

  • Clinical evaluation by a licensed U.S. provider

  • Personalized treatment plan based on medical history and goals

  • Medications and necessary supplies included

  • Follow-up care

  • Unlimited Clinician messaging using patient portal

Pharmacy & Medication Standards

We partner with licensed U.S.-based pharmacies that dispense medications intended for human use and prepare them in accordance with applicable USP standards.
All compounded medications are dispensed pursuant to a valid prescription and are not marketed or sold as research-use products.
Compounded medications are not FDA-approved.

Important Safety Information – GLP-1 therapies are not appropriate for everyone. Do not use if you have a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Tell your clinician about your full medical history and all medications. Treatment decisions are made by a licensed clinician based on clinical evaluation. Individual results vary.

Prescription Care

One month

$249/ month

One month supply • Medication and supplies included • Clinician-authorized • Dispensed by licensed U.S. pharmacies • Shipping included

Prescription Care

Subscribe & Save * Save $207! *

$180 / month

3 month supply • Medication and supplies included • Clinician-authorized • Dispensed by licensed U.S. pharmacies • Shipping included

Status-  (Rx) Only Telehealth consultation required prior to initiation.

What’s Included in Your Care

When clinically appropriate, services may include:

  • Clinical consultations with a licensed clinician

  • Clinical review of medical history and relevant health information

  • Secure clinician messaging through the patient portal

  • Prescription medications and supplies, when prescribed

  • Discreet, unbranded shipping directly to your door

Clinician-Guided. Structured. Designed for Continuity of Care.

This program provides a structured telehealth care experience centered on licensed clinician oversight, individualized evaluation, and ongoing monitoring. Care is designed to support the responsible use of GLP-1–based therapy, with optional supportive nutrients such as vitamin B12 when clinically appropriate, within a medically supervised weight-management program.

All care decisions are guided by evidence-informed clinical judgment and individualized assessment.

What You Can Expect

Clinician-Led Evaluation

Your care begins with a comprehensive telehealth consultation conducted by a licensed U.S. clinician. Medical history, symptom presentation, and available laboratory data are reviewed to determine whether GLP-1–based therapy may be clinically appropriate.

Structured, Data-Informed Monitoring

Laboratory testing and follow-up schedules are ordered at the discretion of the clinician and used to inform ongoing care decisions. Monitoring supports safe use, treatment oversight, and continuity of care throughout the program.

Personalized Care Planning

When treatment is prescribed, clinicians develop an individualized care plan aligned with your clinical profile. Adjustments may be made over time based on follow-up evaluations, laboratory review (when indicated), and patient-reported information.

Prescription-Only Medications

All medications are dispensed pursuant to a valid prescription and fulfilled by licensed U.S. pharmacies. TRTBOSS does not offer research-use, non-prescription, or over-the-counter GLP-1 medications.

Supportive nutrients such as vitamin B12 and glycine are prescribed only when clinically indicated and are not included in all treatment plans.

Ongoing Access & Follow-Up

Patients maintain ongoing access to their care team through secure patient-portal messaging. Follow-up consultations and care adjustments are provided as clinically appropriate and determined by the prescribing clinician.

Medication & Pharmacy Standards

Compounded medications, when prescribed, are prepared for human use by licensed U.S.-based pharmacies in accordance with applicable USP standards.
All medications are dispensed pursuant to a valid prescription and are not manufactured, marketed, or represented as research-use products. Compounded medications are not FDA-approved.

Telehealth Convenience & Privacy

  • 100% digital intake and clinician consultation

  • No waiting rooms or in-person visits required

  • Secure patient portal for care communication

  • Discreet, unbranded packaging to protect privacy

Important Care Context

GLP-1–based therapies are prescribed only after review by a licensed clinician and may not be appropriate for all individuals. Treatment decisions are based on medical history, clinical assessment, and provider judgment. Individual experiences and responses vary. TRTBOSS provides access to clinician-directed telehealth care and does not guarantee specific outcomes. Fees reflect clinical services, care coordination, and pharmacy fulfillment associated with prescribed therapy and do not guarantee treatment eligibility or prescription issuance. All treatment decisions are made solely by licensed clinicians.

This clinician-directed care option may be considered for adults who:

  • Meet clinical criteria commonly evaluated by licensed healthcare providers, such as body composition measures (e.g., BMI ranges) or related metabolic health considerations, as determined during individualized medical review

  • Are being evaluated for GLP-1–based therapy as part of a comprehensive, prescription-only weight-management care plan, when deemed clinically appropriate

  • Have previously pursued nutrition- and lifestyle-focused approaches and are seeking a medically supervised option within a licensed telehealth care framework

  • May be considered for compounded GLP-1 therapy, with supportive nutrients such as vitamin B12, only when determined clinically appropriate by a licensed clinician

  • Prefer individualized evaluation, structured monitoring, and ongoing follow-up within a clinician-led telehealth care environment

  • Understand that all treatment decisions are based on licensed clinician judgment, that therapy may not be appropriate for all individuals, and that individual responses and experiences vary

Route:
Administration route (e.g., injectable or oral, when applicable) is determined solely by the prescribing clinician based on individual evaluation, formulation availability, and clinical considerations.

Dosing & Schedule:
Dosage strength, titration schedule, and duration of therapy are determined by a licensed clinician following review of medical history, treatment goals, and response to therapy. Dosing may be adjusted over time based on follow-up evaluations and clinical judgment.

Supportive Nutrients:
When clinically indicated, supportive nutrients such as vitamin B12 may be prescribed as part of the care plan. Inclusion, formulation, and dosing of these nutrients are determined by the clinician and are not included in all treatment plans.

Patient Guidance:
Patients receive clinician guidance on proper use, administration technique (when applicable), and adherence considerations through the care team and patient portal. Patients should not start, stop, or adjust medication or nutrient dosing without clinician approval.

Monitoring & Follow-Up:
Ongoing monitoring, follow-up consultations, and laboratory testing (when indicated) are ordered at the discretion of the prescribing clinician to support safe use and continuity of care.

Active Ingredient

  • Semaglutide
    A prescription GLP-1 receptor agonist prescribed by a licensed clinician as part of a medically supervised weight-management care program.

Supportive Nutrients 

  • Vitamin B12 (methylcobalamin form determined by the dispensing pharmacy)
    Included when clinically indicated to support normal metabolic and neurologic pathways.

Inactive Ingredients
Inactive ingredients vary by formulation and dispensing pharmacy and may include pharmaceutical-grade excipients required for stability, delivery, or administration. Exact ingredients are provided by the dispensing pharmacy and reviewed by the prescribing clinician.

Mechanisms of Semaglutide + B12

GLP-1 Appetite Signaling

image-Photoroom 1-5

GLP-1 receptor agonists interact with appetite-regulation pathways involved in satiety and hunger signaling, supporting reduced caloric intake in appropriate patients under medical supervision.

GLP-1 Gastric Regulation

Woman eating healthy food-16

GLP-1 activity is associated with delayed gastric emptying, which may contribute to prolonged feelings of fullness as part of a clinician-directed care plan.

Metabolic Pathway Support

Woman eating healthy food-18

GLP-1–based therapies are studied for their role in supporting metabolic and glycemic pathways as part of comprehensive, medically supervised weight-management care.

Vitamin B12 Energy Pathways

Woman eating healthy food

Vitamin B12 supports normal cellular energy metabolism and neurologic function and is commonly evaluated during long-term metabolic or weight-management care.

Neurologic Function Support

Woman eating healthy food-22

B12 plays a role in normal neurologic function and is involved in several foundational physiologic processes. Whether B12 is included in a treatment plan depends on clinician judgment, patient history, and prescribing considerations.

Get Started In 3 Simple Steps

STEP 1

Complete Telehealth Intake

propsteb-img1

A licensed U.S. clinician then reviews your medical history and lab work if required to determine eligibility for care.

STEP 2

U.S Pharmacy Delivery

propsteb-img2

If prescribed, treatment is dispensed by a licensed U.S. pharmacy & Shipped discreetly to your door.

STEP 3

Ongoing Clinician Guided Care

propsteb-img3

Clinicians provide follow-up to review labs and adjust treatment when medically appropriate, supporting individualized care.

Why Patients Choose TRTBOSS

hwhyb-img1

Personalized Plans

Care options aligned to your goals, based on individualized clinical review

hwhyb-img2

Clinician Review + Labs

Start with an online intake. Clinicians may order and review lab work when clinically appropriate.

hwhyb-img3

Ongoing Monitoring

Follow-ups and adjustments are guided by a licensed clinician based on symptoms, history, and lab results.

Evidence-informed options

Evidence-Informed Options

Clinician-guided discussion of options for men’s health concerns, based on your evaluation and medical history.

hwhyb-img5

Care Coordination & Support

Reminders, education, and help navigating next steps—so you know what happens before and after your visit.

hwhyb-img6

Private Care

Confidential support with secure messaging and account access.

prodpway-img

Mechanisms of Semaglutide Based Care With B12

Semaglutide is a GLP-1 receptor agonist that acts by engaging the same signaling pathways as the body’s endogenous glucagon-like peptide-1 hormone. GLP-1 signaling plays a role in appetite regulation by influencing central nervous system pathways involved in hunger and satiety, as well as peripheral processes such as gastric emptying. Through these mechanisms, GLP-1 activity is associated with physiological signals that contribute to feelings of fullness and regulated energy intake within clinician-directed care.

Within some medically supervised care plans, supportive nutrients such as vitamin B12 and glycine may be included when clinically appropriate to support normal physiological pathways during treatment. Vitamin B12 is involved in cellular energy metabolism, red blood cell formation, and neurologic function—systems commonly evaluated in long-term metabolic care. Together, these components are utilized within a structured, prescription-only care framework to support normal biological processes relevant to metabolic regulation. All elements of care are prescribed and managed by licensed clinicians following individualized medical evaluation, with treatment decisions guided by clinical judgment rather than standardized protocols or non-prescription approaches.

Get Started Today

Switch Confidently From Your Current Provider to TRTBOSS

Better Value. Transparent Pricing. Complete Support.

TRTBOSS vs Other Clinics

Feature

  • Initial Lab work + Consult
  • Monthly Treatment Plans
  • Membership Fee
  • Medications
  • Ongoing Physician Communication
  • Supplies
  • Medication Quality
  • Convenience
  • Ongoing Support
  • Research Grade Compounds
  • Labs
  • Cost to start

Other Clinics

  • $149 – $799
  • $199 – $299/month
  • $19 – $49 per month
  • Up to $99 (plus fees)
  • Up to $199 per consult
  • Up to $70 annually
  • Unknown
  • Commute + waiting rooms
  • Extra fees for follow-ups
  • Unknown
  • Extra
  • 3 to 6 months of service

TRTBOSS TRT

  • $160 FSA / HSA Eligible
  • $169/month FSA / HSA Eligible
  • None
  • Included
  • UNLIMITED through your patient portal
  • Included
  • Licensed US pharmacies
  • 100% online, discreet
  • Unlimited
  • Never
  • Included
  • First + Last
hojourneyb-img1
hojourneyb-img8

Trusted.  Legitscript Certified. Confidential.

At TRTBOSS Every step is supported through a clinician-led process with independent, U.S. Licensed clinicians. If prescribed, medications are dispensed and shipped by Licensed U.S LegitScript-certified pharmacies. From expert medical oversight to discreet delivery, We prioritize privacy, secure communications, and clear next steps throughout your experience.

Group 1171276633

Customer Reviews

All Reviews

Posted on August 14, 2023

Samantha D.

TRTBOSS has truly changed my life. The process was smooth, the team was supportive, and the results speak for themselves. I feel more energetic, confident, and focused than ever. It’s easily the best decision I’ve made for my health.

Posted on August 14, 2023

Samantha D.

TRTBOSS has truly changed my life. The process was smooth, the team was supportive, and the results speak for themselves. I feel more energetic, confident, and focused than ever. It’s easily the best decision I’ve made for my health.

Posted on August 14, 2023

Samantha D.

TRTBOSS has truly changed my life. The process was smooth, the team was supportive, and the results speak for themselves. I feel more energetic, confident, and focused than ever. It’s easily the best decision I’ve made for my health.

Posted on August 14, 2023

Samantha D.

TRTBOSS has truly changed my life. The process was smooth, the team was supportive, and the results speak for themselves. I feel more energetic, confident, and focused than ever. It’s easily the best decision I’ve made for my health.

Frequently Asked Questions

“Better” is subjective to your body’s needs. Wegovy® is an FDA-approved, single-ingredient drug. This is a compounded medication customized with B12. It is prescribed for patients who struggle with side effects like fatigue or other side effects, or as clinically directed.

No. This is a custom formulation. We do not offer it as a generic substitute; we offer it as a functional alternative for patients who have a medical necessity for the added ingredients.

Scientific & Clinical References

GLP-1 Appetite & Satiety Signaling
Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity (NEJM, 2021)
Role: Describes GLP-1 receptor activation and its role in appetite regulation and energy intake pathways.
Link: https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

GLP-1 & Gastric Emptying
Study: Effect of Semaglutide on Gastric Emptying, Appetite, and Energy Intake (Diabetes, Obesity & Metabolism, 2021)
Role: Explores delayed gastric emptying and satiety signaling associated with GLP-1 activity.
Link: https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14280

GLP-1 Receptor Mechanisms
Study: GLP-1 Receptor: Mechanisms and Advances in Therapy (Signal Transduction & Targeted Therapy, 2024)
Role: Reviews molecular and physiological GLP-1 receptor pathways involved in metabolic regulation.
Link: https://www.nature.com/articles/s41392-024-01931-z

Vitamin B12 Metabolic Pathways
Study: The Vitamin B12 Metabolism Network (International Journal of Molecular Sciences, 2024)
Role: Details B12’s role in cellular energy metabolism, methylation, and neurologic pathways.
Link: https://www.mdpi.com/1422-0067/25/15/8021

Vitamin B12 & Nervous System Function
Study: B Vitamins in the Nervous System (CNS Neuroscience & Therapeutics, 2019)
Role: Explains biochemical roles of B12 in neurologic function and nervous system maintenance.
Link: https://onlinelibrary.wiley.com/doi/10.1111/cns.13207

Vitamin B12 Mechanism : National Institutes of Health (NIH), Office of Dietary Supplements. Vitamin B12 — Health Professional Fact Sheet. Describes vitamin B12 as a required cofactor in key enzymatic pathways and outlines its roles in neurologic function, red blood cell formation, and DNA synthesis.https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/

Vitamin B12 Clinical Role: StatPearls / NCBI Bookshelf. Vitamin B12 (Cobalamin). Reviews cobalamin’s role as an essential vitamin with broad relevance to neurologic and metabolic processes.https://www.ncbi.nlm.nih.gov/books/NBK559132/

These references describe biological mechanisms of GLP-1 receptor agonists, vitamin B12, and glycine. They do not evaluate any specific compounded formulation. Treatment decisions are made by licensed clinicians following individual medical evaluation.

Medical Disclaimer: TRTBOSS facilitates access to medical services provided by independent, licensed physicians. This program utilizes a Compounded formulation of Semaglutide, Methylcobalamin, and Glycine. This is a compounded medication and is not FDA-approved. It is not a generic version of Wegovy™ or Ozempic™. Compounded medications do not undergo FDA review for safety, efficacy, or quality. Efficacy Notice: While Semaglutide is proven for weight loss, the specific combination of Semaglutide + Glycine has not been evaluated in clinical trials for superior muscle retention compared to Semaglutide alone. Claims regarding “muscle defense” refer to the mechanism of the individual ingredient (Glycine). Risk Warning: Do not use if you have a history of Medullary Thyroid Carcinoma (MTC) or MEN 2. Rx Only.

Start Your Health Assessment Today

Personalized telehealth treatments tailored for you.