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Sildenafil
Sildenafil
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Online Men’s Telehealth for Hormone, Metabolic & Preventive Care

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Licensed U.S.Clinicians & Licensed U.S. Pharmacies

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100% Telehealth, Pharmacy-Shipped to Your Door

Sildenafil (Generic for Viagra®)

Clinician-Directed, Prescription-Only Erectile Dysfunction Care

Sildenafil is an FDA-approved medication that may be prescribed by a licensed clinician to help improve erectile function in men with clinically evaluated erectile dysfunction.

Clinical Considerations

Sildenafil works by inhibiting phosphodiesterase-5 (PDE5), a mechanism that supports increased blood flow to the penis during sexual stimulation. It does not create sexual desire and does not function without arousal.

Active Ingredient
Sildenafil citrate is an FDA-approved medication (generic for Viagra®) that may be prescribed by a licensed clinician when clinically appropriate.

Onset & Duration
Sildenafil is commonly taken prior to sexual activity and may begin working within approximately 30–60 minutes for some individuals. Effects may last for several hours, though response and duration vary.

Common Symptoms Associated With Erectile Dysfunction

Men seeking evaluation for erectile dysfunction may report symptoms such as:

  • Difficulty achieving or maintaining an erection sufficient for sexual activity

  • Reduced erectile firmness or consistency

  • Decreased confidence related to sexual performance

  • Erectile changes associated with stress, aging, or underlying medical conditions

A clinical evaluation helps determine whether these symptoms may be related to erectile dysfunction and whether prescription treatment is appropriate.

Program Structure & Care Process

Telehealth Clinical Evaluation
A licensed U.S. clinician reviews your health history and determines whether prescription sildenafil is clinically appropriate.

Prescription-Only Care
Sildenafil is dispensed only pursuant to a valid prescription and is not available without clinician authorization.

Licensed U.S. Pharmacies
Prescriptions are fulfilled by licensed U.S. pharmacies dispensing FDA-approved medications intended for human use.

Discreet Home Delivery
If prescribed, medication is shipped in discreet packaging directly to your door.

Ongoing Care Access
Patients have access to clinician support through the patient portal for care-related questions, follow-up, or treatment adjustments when clinically indicated.

Individual response and tolerability vary. All treatment decisions are made based on clinician judgment and established medical guidelines.

Program Structure & Care Process

Telehealth Clinical Evaluation
A licensed U.S. clinician reviews your health history and determines whether prescription sildenafil is clinically appropriate.

Prescription-Only Care
Sildenafil is dispensed only pursuant to a valid prescription and is not available without clinician authorization.

Licensed U.S. Pharmacies
Prescriptions are fulfilled by licensed U.S. pharmacies dispensing FDA-approved medications intended for human use.

Discreet Home Delivery
If prescribed, medication is shipped in discreet packaging directly to your door.

Ongoing Care Access
Patients have access to clinician support through the patient portal for care-related questions, follow-up, or treatment adjustments when clinically indicated.

Individual response and tolerability vary. All treatment decisions are made based on clinician judgment and established medical guidelines.

Prescription Care

100MG Tablets – 10 count

$60

Clinician-authorized • Dispensed by licensed U.S. pharmacies • Shipping included

Prescription Care

100MG Tablets – 20 count

$80

Clinician-authorized • Dispensed by licensed U.S. pharmacies • Shipping included

Prescription Care

100MG Tablets – 30 count

$90

Clinician-authorized • Dispensed by licensed U.S. pharmacies • Shipping included

Get Started Today

Telehealth Clinical Evaluation
A licensed U.S. clinician reviews your medical history, current medications, and reported symptoms to determine whether sildenafil is clinically appropriate.

Personalized Care Determination
Treatment decisions, including dosing and frequency, are determined by the clinician based on individual evaluation and established medical guidelines.

Prescription Medication Included (If Approved)
When prescribed, sildenafil is dispensed pursuant to a valid prescription and fulfilled by licensed U.S.-based pharmacies dispensing FDA-approved medications intended for human use.

Discreet Home Delivery
Medications are shipped in secure, unbranded packaging to protect patient privacy.

Follow-Up Care & Ongoing Access
Patients have access to clinician support through the secure patient portal for care-related questions or follow-up, when clinically indicated.

Secure Clinician Messaging
HIPAA-compliant messaging is available through the patient portal for care coordination and clinical communication.

Status: Prescription [RX] Only Care – Telehealth Evaluation Required

Sildenafil should not be used by individuals taking nitrates or certain cardiovascular medications.

This medication is not appropriate for everyone. A licensed clinician reviews your medical history, current medications, and relevant risk factors to determine whether sildenafil is clinically appropriate.

Sildenafil may be considered for adult men who have been clinically evaluated and are experiencing erectile dysfunction, when deemed appropriate by a licensed clinician.

It is most commonly prescribed for individuals who:

  • Experience difficulty achieving or maintaining an erection sufficient for sexual activity

  • Have erectile changes that occur intermittently or situationally

  • Prefer an on-demand, short-acting prescription option rather than daily medication

  • Have been assessed for underlying medical conditions or medication interactions

Sildenafil is intended to be used prior to anticipated sexual activity and requires sexual stimulation to be effective. It does not increase sexual desire and is not intended for continuous daily use unless specifically directed by a clinician.

This medication is not appropriate for everyone. A clinical evaluation is required to assess medical history, cardiovascular risk, and potential contraindications, including the use of nitrates or certain blood pressure medications.

Individual response and tolerability vary. All treatment decisions are made by the supervising clinician based on clinical judgment and established medical guidelines.

Sildenafil is an oral prescription medication intended for use prior to anticipated sexual activity, when prescribed by a licensed clinician.

The medication is taken by mouth and is designed to support erectile function by increasing blood flow to the penis during sexual stimulation. Sildenafil does not create sexual desire and requires arousal to be effective.

Timing of use, dosage strength, and frequency are determined by the supervising clinician based on individual medical evaluation, treatment goals, and tolerability. Patients should follow the clinician-directed instructions provided with their prescription.

Sildenafil should not be used more frequently than prescribed and should not be combined with certain medications, including nitrates. A clinical evaluation is required to assess appropriateness and safety prior to use.

Active Ingredient
Sildenafil Citrate
An FDA-approved phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction, when prescribed by a licensed clinician.

Inactive Ingredients
Inactive ingredients vary by manufacturer and dosage form and may include commonly used pharmaceutical excipients such as binders, fillers, and coatings. Exact inactive ingredients are listed on the medication labeling provided with your prescription.

Mechanisms of Sildenafil

PDE-5 Inhibition

PDE5

Sildenafil inhibits phosphodiesterase-5 (PDE-5), an enzyme involved in regulating blood flow in the penis. This mechanism supports the body’s natural erectile response during sexual stimulation.

Nitric Oxide Pathway Support

cgmp

By affecting PDE-5 activity, sildenafil helps maintain levels of cyclic GMP (cGMP), a signaling molecule associated with smooth muscle relaxation in penile blood vessels.

Enhanced Penile Blood Flow

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Through smooth muscle relaxation, sildenafil may help increase blood flow to the penis during sexual arousal, which is necessary for achieving and maintaining an erection.

Arousal-Dependent Action

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Sildenafil does not initiate erections on its own. Its effects occur only in the presence of sexual stimulation, reflecting its role in supporting—not overriding—the body’s natural physiology.

Get Started In 3 Simple Steps

STEP 1

Complete Telehealth Intake

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A licensed U.S. clinician then reviews your medical history and lab work if required to determine eligibility for care.

STEP 2

U.S Pharmacy Delivery

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If prescribed, treatment is dispensed by a licensed U.S. pharmacy & Shipped discreetly to your door.

STEP 3

Ongoing Clinician Guided Care

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Clinicians provide follow-up to review labs and adjust treatment when medically appropriate, supporting individualized care.

What Patients Say

The onboarding was straightforward and everything was explained clearly. The clinician took time to review my history and labs and answered my questions without rushing. I appreciated the follow-up plan and knowing what to expect next.

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James A.

Weight Managment

Communication was prompt and professional. Scheduling was easy, and the care team helped me understand the steps from assessment to clinician review. Overall, the experience felt organized and respectful of my time!

Robert H

Robert H.

Hormone Care

After my evaluation, the clinician discussed options and went over monitoring. When a prescription was appropriate, my medication was shipped from a licensed U.S. pharmacy and arrived as expected. The check-ins and reminders helped me stay on track.

Bill D

Bill D.

Longevity

Why Patients Choose TRTBOSS

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Personalized Plans

Care options aligned to your goals, based on individualized clinical review

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Clinician Review + Labs

Start with an online intake. Clinicians may order and review lab work when clinically appropriate.

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Ongoing Monitoring

Follow-ups and adjustments are guided by a licensed clinician based on symptoms, history, and lab results.

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Evidence-Informed Options

Clinician-guided discussion of options for men’s health concerns, based on your evaluation and medical history.

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Care Coordination & Support

Reminders, education, and help navigating next steps—so you know what happens before and after your visit.

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Private Care

Confidential support with secure messaging and account access.

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How Sildenafil’s Targeted Mechanism Supports Erectile Function

Sildenafil is an FDA-approved medication (generic for Viagra®) that has been widely studied for its role in supporting erectile function when prescribed by a licensed clinician. It works through a targeted mechanism that supports the body’s natural erectile response rather than overriding normal physiology.

Sildenafil inhibits phosphodiesterase-5 (PDE-5), an enzyme involved in regulating blood flow in penile tissue. By reducing PDE-5 activity, sildenafil helps maintain levels of cyclic GMP (cGMP), a signaling molecule associated with smooth muscle relaxation in penile blood vessels. This process may allow increased blood flow to occur during sexual stimulation, which is necessary for achieving and maintaining an erection.

Unlike treatments that require daily dosing or continuous exposure, sildenafil is commonly used on an on-demand basis and is arousal-dependent. It does not initiate erections on its own and does not increase sexual desire. Its effects occur only in the presence of sexual stimulation, reflecting its role in supporting—rather than replacing—the body’s normal physiological processes.

While erectile dysfunction can have multiple contributing factors—including vascular health, neurological signaling, stress, and medication effects—sildenafil addresses a key blood-flow-related pathway that plays a central role in erectile function for many men. Treatment eligibility, dosing, and frequency are determined by a licensed clinician following medical evaluation, as sildenafil is not appropriate for everyone.

Get Started Today

Switch Confidently From Your Current Provider to TRTBOSS

Better Value. Transparent Pricing. Complete Support.

Make the switch to TRTBOSS and experience affordable, high-quality treatment that’s 100% online, discreet, and designed for your lifestyle.

Comparison TRTBOSS vs Other Clinics

Feature

  • Initial Lab work + Consult
  • Monthly Treatment Plans
  • LegitScript Verified
  • Membership Fee
  • Medications
  • Ongoing Physician Communication
  • Supplies
  • Medication Quality
  • Convenience
  • Ongoing Support
  • Research Grade Compounds
  • Labs
  • Cost to start

Other Clinics

  • $149 – $799
  • $199 – $299/month
  • Unknown
  • $19 – $49 per month
  • Up to $99 (plus fees)
  • Up to $199 per consult
  • Up to $70 annually
  • Unknown
  • Commute + waiting rooms
  • Extra fees for follow-ups
  • Unknown
  • Extra
  • 3 to 6 months of service

TRTBOSS TRT

  • $160 FSA / HSA Eligible
  • $160/month FSA / HSA Eligible
  • Yes
  • None
  • Included
  • UNLIMITED through your patient portal
  • Included
  • Licensed US pharmacies
  • 100% online, discreet
  • Unlimited
  • Never
  • Included
  • First + Last
Start My TRT Journey

The Proof Is in Their Journey

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Trusted. Certified. Confidential.

At TRTBOSS Every step is supported through a clinician-led process with independent, U.S. Licensed clinicians. If prescribed, medications are dispensed and shipped by Licensed U.S LegitScript-certified pharmacies. From expert medical oversight to discreet delivery, We prioritize privacy, secure communications, and clear next steps throughout your experience.

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Customer Reviews

All Reviews

Posted on August 14, 2023

Samantha D.

TRTBOSS has truly changed my life. The process was smooth, the team was supportive, and the results speak for themselves. I feel more energetic, confident, and focused than ever. It’s easily the best decision I’ve made for my health.

Posted on August 14, 2023

Samantha D.

TRTBOSS has truly changed my life. The process was smooth, the team was supportive, and the results speak for themselves. I feel more energetic, confident, and focused than ever. It’s easily the best decision I’ve made for my health.

Posted on August 14, 2023

Samantha D.

TRTBOSS has truly changed my life. The process was smooth, the team was supportive, and the results speak for themselves. I feel more energetic, confident, and focused than ever. It’s easily the best decision I’ve made for my health.

Posted on August 14, 2023

Samantha D.

TRTBOSS has truly changed my life. The process was smooth, the team was supportive, and the results speak for themselves. I feel more energetic, confident, and focused than ever. It’s easily the best decision I’ve made for my health.

Frequently Asked Questions

It is “real” Sildenafil, which is the active ingredient in Viagra®. Think of it like buying generic Ibuprofen vs. Advil®—the molecule is identical, the safety profile is identical, but the price is vastly lower because you aren’t paying for their TV commercials.

Yes. This is a powerful, FDA-approved medication. However, we have streamlined the process. You will complete a simple medical intake online, and our U.S. licensed medical team will review it. If approved, they write the prescription and we ship it.

Yes. In fact, that is one of its best uses. By physically ensuring blood flow, it helps break the psychological cycle of performance anxiety (the “fear of failure”), allowing your mind to relax because your body is handled.

100%. The package is a plain mailer. It gives no indication of what is inside or where it came from.

Prescription only. Not for everyone. Individual response varies. Sildenafil should not be used with nitrates or certain cardiovascular medications. Treatment decisions are made by a licensed clinician based on medical evaluation.

Medical Citations
Study: Efficacy in Broad Populations Citation: Goldstein, I., et al. (1998). “Oral Sildenafil in the Treatment of Erectile Dysfunction.” New England Journal of Medicine. Summary: This landmark study established the gold standard for Sildenafil. It found that 69% to 80% of sexual attempts were successful in men taking Sildenafil, compared to only 22% in the placebo group. This proves that the chemical mechanism is highly effective regardless of the patient’s history.

Study: Patient Satisfaction & Reliability Citation: Palumbo, F., et al. (2001). “Sildenafil: Efficacy and safety in daily clinical experience.” European Urology. Summary: In a real-world clinical setting, Sildenafil demonstrated an overall success rate of 77%. The study highlighted that the medication was effective across various causes of ED (psychogenic, organic, and mixed), reinforcing its versatility.

Study: Duration of Action Citation: Moncada, I., et al. (2004). “Efficacy of Sildenafil Citrate at 12 Hours after Dosing.” Summary: While marketed as a 4-hour window, this study showed that many men were still able to achieve erections sufficient for intercourse up to 12 hours after dosing, suggesting the window of opportunity may be wider for some users.

Positive Health Publications
Journal of Sexual Medicine: Cites Sildenafil as a first-line pharmacotherapy for ED due to its high safety profile and patient tolerance.

Medical News Today: Reports that the shift to telehealth and generic Sildenafil has “revolutionized access,” removing barriers of cost and embarrassment.

The American Journal of Medicine: Highlights that PDE5 inhibitors like Sildenafil may have secondary benefits for cardiovascular circulation and endothelial health.

IMPORTANT SAFETY INFORMATION
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Do not take Sildenafil if you:

Take any medicines called nitrates (often used for chest pain), such as nitroglycerin. This combination can cause an unsafe, life-threatening drop in blood pressure.

Use recreational drugs called “poppers” like amyl nitrate and butyl nitrate.

Are allergic to sildenafil or any of the inactive ingredients.

Potential Side Effects: The most common side effects of Sildenafil include headache, flushing, upset stomach, abnormal vision (such as changes in color vision or blurred vision), stuffy or runny nose, back pain, muscle pain, nausea, dizziness, and rash.

Serious Risks:

Priapism: If you have an erection that lasts more than 4 hours, get medical help right away. If it is not treated immediately, priapism can permanently damage your penis.
Sudden Vision Loss: Sildenafil has been linked to sudden vision loss in one or both eyes. If you experience this, stop taking the medication and call your doctor right away.
Sudden Hearing Decrease/Loss: Some patients have reported a sudden decrease or loss of hearing, sometimes ringing in the ears and dizziness.
This is not a complete list of side effects. Please review the full Prescribing Information [Link to FDA PI] and Patient Information [Link] before starting treatment.

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